DeCS Server - List Exact Term

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DeCS

Descriptor English:

STAT Transcription Factors

Descriptor Spanish:

Factores de Transcripción STAT

Descriptor Portuguese:

Fatores de Transcrição STAT

Synonyms English:

STAT (Signal Transducers and Activators of Transcription) Proteins
Transcription Factors, STAT

Tree Number:

Definition English:

A family of transcription factors containing SH2 DOMAINS that are involved in CYTOKINE-mediated SIGNAL TRANSDUCTION. STAT transcription factors are recruited to the cytoplasmic region of CELL SURFACE RECEPTORS and are activated via PHOSPHORYLATION. Once activated they dimerize and translocate into the CELL NUCLEUS where they influence GENE expression. They play a role in regulating CELL GROWTH PROCESSES and CELL DIFFERENTIATION. STAT transcription factors are inhibited by SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS and PROTEIN INHIBITORS OF ACTIVATED STAT.

Indexing Annotation English:

general; prefer specifics

History Note English:

2006

Allowable Qualifiers English:

Record Number:

50795

Unique Identifier:

D050791

Similar:

DeCS